Surmounting the Multiple-Minima Problem in Protein Folding
نویسندگان
چکیده
Protein folding is a very difficult global optimization problem. Furthermore it is coupled with the difficult task of designing a reliable force field with which one has to search for the global minimum. A summary of a series of optimization methods developed and applied to various problems involving polypeptide chains is described in this paper. With recent developments, a computational treatment of the folding of globular proteins of up to 140 residues is shown to be tractable.
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عنوان ژورنال:
- J. Global Optimization
دوره 15 شماره
صفحات -
تاریخ انتشار 1999